INITIATION OF MITOCHONDRIAL PROTEIN SYNTHESIS AT BIRTH † 1293
نویسندگان
چکیده
منابع مشابه
Dependence of Mitochondrial Protein Synthesis Initiation on Formylation of the Initiator Methionyl-tRNA,
The effect of N’“-formyl-H,folate on mitochondrial peptide chain initiation has been studied in isolated mitochondria of Saccharomyces cerevisiae. The addition of N”‘-formyl-H,folate strongly stimulates the incorporation of amino acids into mitochondrial protein at both 6 and 15 mu Mg2+. Still higher stimulation (up to IO-fold) has been obtained in the production of de nouo synthesized initial ...
متن کاملDisorders of mitochondrial protein synthesis.
Mitochondrial tRNA gene mutations, including heteroplasmic deletions that eliminate one or more tRNAs, as well as point mutations that may be either hetero- or homoplasmic, are associated with a wide spectrum of human diseases. These range from rare syndromic disorders to cases of commoner conditions such as sensorineural deafness or cardiomyopathy. The disease spectrum of mutations in a given ...
متن کاملDependence of mitochondrial protein synthesis initiation on formylation of the initiator methionyl-tRNAf.
The effect of N10-formyl-H4folate on mitochondrial peptide chain initiation has been studied in isolated mitochondria of Saccharomyces cerevisiae. The addition of N10-formyl-H4-folate strongly stimulates the incorporation of amino acids into mitochondrial protein at both 6 and 15 mm Mg2+. Still higher stimulation (up to 10-fold) has been obtained in the production of de novo synthesized initial...
متن کاملInitiation of protein synthesis in HeLa cells.
Initiation of protein synthesis in HeLa cells has been synchronized by exposure of the cells to fluoride. Double-labeling of such cells for short pulses with [(35)S]methionine and a tritiated amino acid, followed by Edman degradation of the puromycin-released nascent peptides, has shown that the percent of N-terminal methionine incorporated compared to total incorporation is significantly highe...
متن کاملInitiation of protein synthesis in eukaryotes.
The study of the regulation of initiation of protein synthesis has recently gained momentum because of the established relationship between translation initiation, cell growth and tumorigenesis. Therefore much effort is devoted to the role of protein kinases which are activated in signal transduction cascades and which are responsible for the phosphorylation of a number of initiation factors. T...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1996
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-199604001-01316